Endocrine Abstracts

Introduction: Cushing’s syndrome describes symptoms associated with prolonged exposure to inappropriately high levels of cortisol. It may be increased as a result of high ACTH production in the pituitary gland or from tumours outside pituitary–adrenal system.Case report: Patient 34 years old was hospitalised with complaints of muscle weakness, shooting-pain in thoracic, lumbar spine, decreased height, amenorrhea, arterial hypertension and chang...

Introduction: Lipohypertrophy (LH) is a chronic complication of diabetes mellitus that could develop in any age, any injection site, and be any size. At present time, new method, as ultrasonography of subcutaneous fat, of LH diagnostics were appeared.Design: The aim of this study has been to estimate efficiency of insulinotherapy in diabetic patients after LH was diagnosed by ultrasonography. This study was done on 50 diabetic patients (31 females and 19...

Adrenal incidentaloma (AI) in patients with cancer poses diagnostic challenge for doctors. We present clinical case of generalised metastatic bone diseases and adrenal mass.Male 59 years old asked the second opinion about incidental adrenal mass, which was suspected for adrenal cancer by urologist. His medical anamnesis began in April of 2015 with severe generalised bone pain. The whole body MRI/CT detected multiple bone lesions, adrenal mass (57×45...

Introduction: Lipohypertrophy (LH) is a chronic complication of diabetes mellitus that caused by frequent subcutaneous injections of insulin. Nowadays, on the basis of results of ultrasonography of subcutaneous fat prevalence of LH in diabetic patients is still high.Design: The aim has been to develop prevention of insulin induced LH in diabetic patients. This study was done on 140 diabetic patients who had been under the treatment with insulin a mean 8 ...

Background: Adrenal insufficiency (AI) in pregnant women is difficult to manage because of similarity between clinics of decompensation of AI and gestational toxicosis. Objective difficulty is absence of clinical guidelines of management of pregnant patients with AI. We present a clinical case where the management of pregnant patient was not careful, which led to overdose and iatrogenic hypercortisolism.Clinical case: Pregnant woman, 29years old, asked s...

Background: Pheochromocytoma (Ph) is the tumor that is fatal if do not suspect and treat it on time. It is supposed that size of tumor is correlated with its synthetic activity. Here we present a clinical case of giant Ph with low synthetic activity that could have been recognized as adrenal cancer, which, in turn, may have led to wrong treatment.Clinical case: Young woman, 28 years old, presented with the adrenal incidentaloma. She had not any complaint...

Introduction: Lipohypertrophy (LH) is a chronic complication of diabetes mellitus that caused by frequent subcutaneous injections of insulin. Nowadays, LH were modified due to good quality modern insulin and expansion their concentration. As a result, some difficulties of diagnosis were appeared.Design: The aim of this study has been to develop the estimation risk model of insulin induced LH in diabetic patients. This study was done on 140 diabetic patie...

Introduction: Lipohypertrophy (LH) is a chronic complication of diabetes mellitus that caused by frequent s.c. injections of insulin. Nowadays, LH were modified due to good quality modern insulin and expansion their concentration. As a result, some difficulties of diagnosis were appeared.Design: The aim of this study has been to compare the frequency of insulin induced LH in diabetic patients revealed by ultrasonography of subcutaneous fat with those fou...

Currently, it has been established that obesity is a heterogeneous disease. There are metabolically healthy (MHO) and metabolically unhealthy obesity (MNHO) depending on the presence of cardiometabolic disorders. Potential factors that differentiate obesity into phenotypes include the gut microbiome and endocrine activity of adipose and muscle tissue. Purpose of the study was to compare intestinal microbiome and adipomyokine profile in patients with different obesity phenotype...

Background: Paraganglioma is a rare neuroendocrine tumor from extra-adrenal chromaffin cells of the sympathetic paravertebral ganglia of thorax, abdomen, and pelvis. About 15–20% of chromaffin-cell tumors are paragangliomas. In most cases paragangliomas produce catecholamines in large concentrations and the lack of treatment can lead to cardiovascular and cerebral catastrophes. That is why early diagnosis of this tumor is so important and, consequently, knowledge of its d...